@article{PATIL_2023, title={Patil, S. Role of Lactate Dehydrogenasein COVID-19 pneumonia: a single tertiary care center follow-up experienceof1000casesinIndia: Role oflactate dehydrogenase in covid-19pneumonia}, volume={1}, url={https://onehealthjournal.com/index.php/pub/article/view/2}, DOI={10.5281/zenodo.7521677}, abstractNote={<p>Objective: The role of various inflammatory markers has been documented during the evaluation of COVID-19 pneumonia. In the present study, the role of lactate dehydrogenase (LDH) in COVID19 pneumonia in predicting severity, oxygenation status and confirming response to interventions and final radiological outcome was examined.</p> <p>Methods: This observational study included 1000 PCR-confirmed COVID-19 cases. All cases were assessed with lung involvement documented and categorized on thorax computer tomography, oxygen saturation, inflammatory marker as LDH at the entry point and follow-up. Age, gender, comorbidity and use of bi-level positive airway pressure/noninvasive ventilation (BPAP/NIV) and outcome as with or without lung fibrosis as per tomography severity were observed.</p> <p>Results: In the study of 1000 COVID-19 pneumonia cases. Tomography severity score at the entry point has significantly associated with LDH level (p<0.001). LDH level has a significant association with the duration of illness and oxygen saturation at the entry point (p<0.001). BPAP/NIV requirement during the course of hospitalization has a significant association with LDH level (p<0.001). Follow-up LDH titer during hospitalization as compared to entry point abnormal LDH has a significant association in post-covid lung fibrosis (p<0.001). Follow-up LDH titer during hospitalization as compared to entry point normal LDH has a significant association in post-covid<br />lung fibrosis (p<0.001).</p> <p>Conclusion: LDH has documented a important role in COVID-19 pneumonia in predicting the severity of illness and progression of pneumonia. Sequential LDH titers will help assess response to treatment during hospitalization and analyse post-covid lung fibrosis.</p>}, number={1}, journal={Journal of One Health Research}, author={PATIL, DR SHITAL}, year={2023}, month={Oca.}, pages={7–14} }