Patil, S. Role of LDH (Lactate Dehydrogenase) in COVID-19 pneumonia: A large single center Prospective, observational, long term follow-up experience of 1000 cases in tertiary care setting in India
Role of LDH (Lactate Dehydrogenase) in COVID-19 pneumonia
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https://doi.org/10.5281/zenodo.7521677Keywords:
COVID-19 pneumonia, LDH, Oxygen saturation, Inflammatory markerAbstract
Abstract:
Objectives: Robust data of LDH is available as prognostic marker in hematology, malignancy, pneumocystis pneumonia, and we have analyzed its usefulness in COVID-19 pneumonia.
Methods: Prospective, observational, follow up study, included 1000 COVID-19 cases confirmed with RT PCR. All cases were assessed with lung involvement documented and categorized on HRCT (high resolution computerized tomography) thorax, oxygen saturation, inflammatory marker as LDH at entry point and follow up. Age, gender, Comorbidity and use BIPAP/NIV and outcome as with or without lung fibrosis as per CT severity were key observations. Statistical analysis is done by using Chi square test.
Results: In study of 1000 COVID-19 pneumonia cases, age (<50 and >50 years) and gender (male versus female) has significant association with LDH in predicting severity of covid 19 pneumonia [p<0.00001] & [p<0.010] respectively. CT severity score at entry point with LDH level has significant association. [p<0.00001] LDH level has significant association with duration of illness. [p<0.00001] Comorbidity as diabetes mellitus, hypertension, COPD, IHD & obesity has significant association with LDH level. [p<0.00001] LDH level has significant association with oxygen saturation. [p<0.00001] BIPAP/NIV requirement during course of hospitalization has significant association with LDH level. [p<0.00001] Timing of BIPAP/NIV requirement in critical care setting has significant association with LDH level. [p<0.00001] Follow-up LDH titer during hospitalization as compared to entry point abnormal LDH has significant association in post-covid lung fibrosis [p<0.00001] Follow-up LDH titer during hospitalization as compared to entry point normal LDH has significant association in post-covid lung fibrosis [p<0.00001]
Conclusion: LDH is easily available, and universally acceptable inflammatory marker in COVID-19 pandemic and documented very crucial role in COVID-19 pneumonia in predicting severity of illness, assessing response to treatment and analyzing outcome during hospitalization.
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