Patil, S. Role of Lactate Dehydrogenasein COVID-19 pneumonia: a single tertiary care center follow-up experienceof1000casesinIndia
Role oflactate dehydrogenase in covid-19pneumonia
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Anahtar Kelimeler:COVID-19 pneumonia, LDH, Oxygen saturation, Inflammatory marker
Objective: The role of various inflammatory markers has been documented during the evaluation of COVID-19 pneumonia. In the present study, the role of lactate dehydrogenase (LDH) in COVID19 pneumonia in predicting severity, oxygenation status and confirming response to interventions and final radiological outcome was examined.
Methods: This observational study included 1000 PCR-confirmed COVID-19 cases. All cases were assessed with lung involvement documented and categorized on thorax computer tomography, oxygen saturation, inflammatory marker as LDH at the entry point and follow-up. Age, gender, comorbidity and use of bi-level positive airway pressure/noninvasive ventilation (BPAP/NIV) and outcome as with or without lung fibrosis as per tomography severity were observed.
Results: In the study of 1000 COVID-19 pneumonia cases. Tomography severity score at the entry point has significantly associated with LDH level (p<0.001). LDH level has a significant association with the duration of illness and oxygen saturation at the entry point (p<0.001). BPAP/NIV requirement during the course of hospitalization has a significant association with LDH level (p<0.001). Follow-up LDH titer during hospitalization as compared to entry point abnormal LDH has a significant association in post-covid lung fibrosis (p<0.001). Follow-up LDH titer during hospitalization as compared to entry point normal LDH has a significant association in post-covid
lung fibrosis (p<0.001).
Conclusion: LDH has documented a important role in COVID-19 pneumonia in predicting the severity of illness and progression of pneumonia. Sequential LDH titers will help assess response to treatment during hospitalization and analyse post-covid lung fibrosis.
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