AİLE HEKİMLİĞİ POLİKLİNİĞİNDE HİPOTİROİDİ TANISI ALAN HASTALARDA TİROİD OTO-ANTİKORLARININ POZİTİFLİK ORANLARININ RETROSPEKTİF OLARAK DEĞERLENDİRİLMESİ
HİPOTİROİDİ TANISI ALAN HASTALARDA TİROİD OTO-ANTİKORLARININ POZİTİFLİĞİ
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https://doi.org/10.5281/zenodo.10463243Anahtar Kelimeler:
Tiroid otoantikoru- Anti TPO- Anti TGÖzet
Objective: The aim of this study is to determine the thyroid autoantibody positivity of hypothyroid patients who applied to Kartal Dr Lütfi Kırdar City Hospital Family Medicine Polyclinics between 1.01.2022 and 31.12.2022.
Method: The population of our descriptive study consists of patients diagnosed with hypothyroidism who applied to Kartal Dr Lütfi Kırdar City Hospital Family Medicine Polyclinics between 1.01.2022 and 31.12.2022. The patients were scanned through the hospital information system. Age and gender information of the patients were recorded through the hospital information system. Thyroid autoantibodies were evaluated as positive or negative considering reference values.
Results: As a result of the study, 56.7% of the patients; anti TPO positivity and 20.9% (n=89) anti TG positivity. The rate of isolated anti-TPO positivity is 37.6%, and isolated anti-TG positivity is 1.7%. The rate of patients who are positive for both antibodies is 19.2%.
Conclusion: Thyroid autoantibody positivity depends on genetic and environmental factors. In this respect, different values can be obtained in different communities. There is a need for broad-based studies on this subject in our country.
Referanslar
Almandoz JP, Gharib H. Hypothyroidism: Etiology, diagnosis, and management. Med Clin North Am 2012; 96 (2): 203-221.
Atmaca M, Tuzcular Vural Z, Gönnenç I,Arslan ME. Polikliniğimize başvuran hastalarda tiroid otoantikorlarının (Anti-Tpo ve Anti-Tg) pozitiflik oranlarının retrospektif olarak değerlendirilmesi. Turkish Family Physician 2015; 7(1):6-15.
Türkiye Endokrinoloji ve Metabolizma Derneği. Tiroid Hastalıkları Tanı ve Tedavi Kılavuzu.Ankara 2023.
Pederson OM, Aordal NP, Larssen TB, Varhauq JE, Myking O, Vik-Mo H. The value of ultrasonography in predicting autoimmune thyroid disease. Thyroid 2000;10:251-9.
V 1Jacobson EM, Huber A, Tomer Y. The HLA gene complex in thyroid auto immunity: from epidemiology to etiology. J Autoimmun 2008;30(1-2):58- 62.
Mc Leod DSA,Cooper DS. The incidence and prevalence of thyroid autoimmunity Endocrine. 2012 Oct;42(2):252-65.
K Aho, P Virkola, OP Heinonen, Determination of thyroglobulin antibodies using chromic chloride as a coupling reagent. Evaluation of the test and characterization of antibodies in an adult population. Acta Endocrinol (Copenh) 68(1), 196–202 (1971)
Gordin A, Heinonen OP, Saarinen P, Lamberg BA. Serum-thyrotrophin in symptomless autoimmune thyroiditis. Lancet. 1972 ;1(7750):551-4.
Bjøro T, Gaarder PI, Smeland EB, Kornstad L. Thyroid antibodies in blood donors: prevalence and clinical significance. Acta Endocrinol (Copenh). 1984;105(3):324-9.
LM Prentice, DI Phillips, D Sarsero, K Beever, SM McLachlan, BR Smith. Geographical distribution of subclinical autoimmune thyroid disease in Britain: a study using highly sensitive direct assays for autoantibodies to thyroglobulin and thyroid peroxidase. Acta Endocrinol (Copenh)1990; 123(5), 493–498.
Bjoro T, Holmen J, Krüger O, Midthjell K, Hunstad K, Schreiner T, Sandnes L, Brochmann H. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol 2000;143(5):639-47.
O'Leary PC, Feddema PH, Michelangeli VP, Leedman PJ, Chew GT, Knuiman M, Kaye J, Walsh JP. Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study. Clin Endocrinol (Oxf). 2006;64(1):97-104.
Pedersen IB, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Laurberg P. Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrinol (Oxf). 2003;58(1):36-42.
Aghini-Lombardi F, Antonangeli L, Martino E, Vitti P, Maccherini D, Leoli F, Rago T, Grasso L, Valeriano R, Balestrieri A, Pinchera A. The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin Endocrinol Metab. 1999;84(2):561-6.
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